Patients with already compromised lung conditions may be at higher risk for more severe complications from COVID-19. Specifically, people who smoke or vape, or use opioids or methamphetamine may face heightened risk. In addition, chronic opioid use already increases the risk of slowed breathing due to hypoxemia, which can lead to cardiac and pulmonary complications that may result in overdose and death. While all people should be taking precautions to prevent exposure to COVID-19, this is particularly critical for higher risk groups, including people who smoke, vape, or use opioids or methamphetamine. Dr. Volkow urges clinicians to be alert to the possibility of increased risks for adverse COVID-19 outcomes in these patients.