Individual with drug addiction continue to use their substances in the face of a long duration of critical consequences in significant areas of their lives, including medical problems, legal problems, relational problems, and employment problems. The drive to use often is stronger than one’s love for a significant other or a child; stronger than loyalty to an employer or a friend; and stronger than one’s values or even spiritual tenets. Persons with addictive disease continue to use long after any rational individual would choose to do so. This article provides a brief summary of one factor, among many, involved in the power of addictive disease: the role of fear of withdrawal.